SUITABILITY OF BIOLOGY TEACHER’S LEARNING OBJECTIVE AND AUTHENTIC ASSESSMENT

This research aimed to describe suitability between learning objective and authentic assessment that made by certified biology teacher in Sidoarjo. This research is descriptive research with qualitative approach. Sample of this research is 27 certified biology teacher of 46 total population certified biology teacher in Sidoarjo. Techniques of collecting data done by documentation and gave self-assessment questionnaires teacher. Authentic assessment profile analysis result are known for 98,02% of teachers using authentic assessment. 98,02% of teacher who used authentic assessment, at 63,82% of teacher prepared learning objectives appropriate to the task and rubric. Keywords: learning objective, authentic assessment, Biology’s teache

Investigation of the anti-aging properties of allicin from Allium sativum L bulb extracts by a reverse docking approach

Purpose: To analyze the potential of Allium sativum bulb extract in curing premature aging using reverse docking method.Methods: Ligand samples were retrieved from a PubChem database, allicin CID 65036,epigallocatechin gallate CID 65064, and pedunculagin CID 442688. To improve reliability, protein targets were predicted using three web services (PharmMapper, SuperPred and Swiss Target Prediction). Molecular docking was conducted to predict the interaction between Allium sativum bioactive as ligands and leukocyte elastase as protein target using PyRx 0.8 software. To be sure of the drug potential of the bioactive, DruLiTo software was used for the evaluation. Visualization and interaction analysis were performed by PyMol and Ligplus software.Results: The results showed that allicin has the highest potential as a candidate for premature-aging treatment, as evidenced by the highest binding affinity (-8.7 kcal/mol) to leukocyte elatase compared with epigallocatechin (-7.2 kcal/mol) and pedunculagin (-7.8 kcal/mol). Allicin acted as a leukocyte elatase inhibitor, with its binding stability facilitated by hydrogen bonding and hydrophobic interactions.Conclusion: Allicin has a potential as a leukocyte elastase inhibitor based on its binding affinity and intermolecular interactions. Thus, allicin is a potential anti-aging drug candidate based on Lipinski’s rule.Keywords: Anti-aging, Allicin, Leukocyte elastase inhibitor, Protein target analysis, Binding affinity, Reverse dockin

Pengembangan Buku Ajar Biologi Sel dengan Pendekatan Bioinformatika

Textbooks are learning guide books used by students in order to help achieve the goals of national education. Development of textbooks is one of the ways in which to facilitate the achievement of learning indicators. Development of Cell Biology textbooks by using bioinformatics approaches Dick and Carey development model. Textbooks developed validated by subject matter experts, instructional media experts, individual testing 15 students, and 15 students were group trial. Validation results matter experts declared feasible by 84% in good categories. The results of the validation study media experts declared feasible by 82.4% in good categories.Buku ajar merupakan buku panduan pembelajaran yang digunakan oleh siswa guna membantu mencapai tujuan pendidikan nasional. Pengembangan buku ajar merupakan salah satu cara yang dilakukan untuk memfasilitasi tercapainya indikator pembelajaran. Pengembangan buku ajar Biologi Sel dengan pendekatan Bioinformatika menggunakan model pengembangan Dick and Carey. Buku ajar yang dikembangkan divalidasi oleh ahli materi, ahli media pembelajaran, 15 mahasiswa uji coba perorangan, dan 15 mahasiswa uji coba kelompok sedang. Hasil validasi ahli materi menyatakan layak sebesar 84% dengan kategori baik. Hasil validasi ahli media pembelajaran menyatakan layak sebesar 82,4% dengan kategori baik

PENGEMBANGAN BUKU AJAR BIOLOGI SEL DENGAN PENDEKATAN BIOINFORMATIKA

Textbooks are learning guide books used by students in order to help achieve the goals of national education. Development of textbooks is one of the ways in which to facilitate the achievement of learning indicators. Development of Cell Biology textbooks by using bioinformatics approaches Dick and Carey development model. Textbooks developed validated by subject matter experts, instructional media experts, individual testing 15 students, and 15 students were group trial. Validation results matter experts declared feasible by 84% in good categories. The results of the validation study media experts declared feasible by 82.4% in good categories. Buku ajar merupakan buku panduan pembelajaran yang digunakan oleh siswa guna membantu mencapai tujuan pendidikan nasional. Pengembangan buku ajar merupakan salah satu cara yang dilakukan untuk memfasilitasi tercapainya indikator pembelajaran. Pengembangan buku ajar Biologi Sel dengan pendekatan Bioinformatika menggunakan model pengembangan Dick and Carey. Buku ajar yang dikembangkan divalidasi oleh ahli materi, ahli media pembelajaran, 15 mahasiswa uji coba perorangan, dan 15 mahasiswa uji coba kelompok sedang. Hasil validasi ahli materi menyatakan layak sebesar 84% dengan kategori baik. Hasil validasi ahli media pembelajaran menyatakan layak sebesar 82,4% dengan kategori baik

ANALISIS FAKTOR YANG MEMPENGARUHI KEPATUHAN PENGAMBILAN OBAT DIABETES MELITUS PADA PESERTA PROGRAM RUJUK BALIK (Studi di Apotek Program Rujuk Balik Wilayah Surabaya)

Medication adherence is very important for diabetic patients to achieve nearnormal blood sugar levels. Medication adherence will be achieved if the patient has adequate amounts of a drug by picked up on time. This study aims to analyze the factors that influence medication refill adherence by PRB beneficiaries with diabetes mellitus served at pharmacies in collaboration with BPJS Kesehatan in Surabaya. Medication refill adherence data is obtained from a control book to determine refill date. Adherence was defined as Medication Possession Ratio (MPR) ≥ 80%. This research uses observational analytic cross-sectional approach, simple random sampling with 73 respondents. Respondents were PRB beneficiaries who received diabetes mellitus drug services for 3 consecutive months in the range from October 2017 to February 2018. Socio-demographic variables, therapy variables, patient variables, condition variables, and health care system variables were examined for each patients. The results of the research show 76.7% of respondents have high refill adherence. The results of logistic regression analysis showed that knowledge about drug services in PRB and drug therapy for diabetes mellitus (p = 0.009), intention to pick up diabetes mellitus drugs on time (p = 0.024), and pharmacy staff behavior (p = 0.022) have a statistically significant effect on medication refill adherence. It is recommended that need to increase the role of health professionals and programs aimed at educating about antihyperglycemic. Besides that, the role of pharmacy staff needs to be improved in providing drug education and identification of drug therapy problem with a friendly attitude